Sudan's association with learning stretches back to the earliest chapters of African civilisation. Along the middle Nile, the kingdoms of Kerma, Kush and Meroe sustained one of the continent's oldest literate cultures. From its capital at Meroe — roughly 200 kilometres north-east of modern Khartoum — the Kingdom of Kush governed the Nile for centuries (from around 590 BC to the fourth century AD) and developed the Meroitic script, regarded as the second-oldest writing system in Africa after Egyptian hieroglyphs, using an alphabetic set of some twenty-three signs. The royal cemeteries of the region, with their close-set pyramids, were inscribed on UNESCO's World Heritage List in 2011, and Sudan today holds more than six thousand registered archaeological sites — a tangible record of ideas, administration and craft along the Nile.

With the spread of Islam from the sixteenth century, a second great tradition of scholarship took root. The Funj Sultanate, founded in 1504, fostered Arabic learning and religious study, and along the White and Blue Niles a network of khalwas — Qur'anic schools where students memorised the Qur'an and studied Arabic and Islamic jurisprudence — became the backbone of popular education. Sufi brotherhoods linked Sudanese towns to the wider Muslim world, and the country earned a lasting reputation as a meeting-point of African and Arab-Islamic scholarship. That heritage carried into the modern era through institutions such as the Omdurman Scientific Institute, whose origins reach back to the early twentieth century (around 1901–1912) and which grew into Omdurman Islamic University in 1965.

Modern higher education in Sudan is usually dated to Gordon Memorial College, opened in Khartoum on 8 November 1902. It began modestly, but expanded steadily: the Kitchener School of Medicine — Sudan's first — was founded in 1924, and by mid-century a cluster of higher schools in engineering, law, agriculture and the sciences had formed around the college. In 1947 the institution entered a "special relationship" with the University of London, was renamed University College Khartoum in 1951, and achieved full independent status as the University of Khartoum in 1956, the year of Sudan's independence. Today the university comprises more than twenty faculties and research institutes and a main library holding over 400,000 volumes.

Through the second half of the twentieth century, Sudanese universities exercised a regional academic influence well beyond the country's borders. The University of Khartoum in particular became one of the most respected seats of learning in Africa and the Arab world, producing scholars, scientists, jurists and writers of international standing — among them the novelist Tayeb Salih, the economist and prime minister Abdalla Hamdok, and the political leader John Garang. Sudanese academics helped staff new universities across the region, and the country's medical and Islamic-studies graduates earned recognition far afield.

This legacy — ancient, Islamic and modern in turn — remains Sudan's enduring intellectual foundation. Even as the sector faces severe disruption from the conflict that began in April 2023, the institutions, scholarly networks and traditions built over more than a century, and the deeper heritage of Nile-Valley learning behind them, continue to define Sudan's place in the story of African and Arab education.